Therapy with lipid-altering agents should be only one component of multiple risk factor intervention in individuals at significantly increased risk for atherosclerotic vascular disease due to Colchicine is a substrate for cytochrome P450 3A4 (CYP3A4). In-vitro studies have indicated that the ortho-and para-hydroxylated metabolites of atorvastatin may be CYP3A4/5 competitive and mechanism-based inhibitors (MBI). Colchicine (Brand: Colcrys) is an alkaloid used to prevent or treat gout attacks (flares), and is also used to prevent attacks of pain in the abdomen, chest, or joints caused by a certain inherited disease (familial Mediterranean fever). Current Topics in Drug Interactions 2018; Myopathy From Colchicine and Statins (7/2018) references; Endothelin Receptor Antagonist Drug Interactions (6/2018) references Learn about Zocor (Simvastatin) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications. Simvastatin oral tablet is available as a brand-name drug and a generic drug. Brand name: Zocor. Simvastatin comes in two forms: an oral tablet and an oral suspension. For the treatment of hypercholesterolemia, including hyperlipidemia, hyperlipoproteinemia, or hypertriglyceridemia, as an adjunct to dietary control; and for reduction in cardiovascular mortality, including myocardial infarction prophylaxis and stroke prophylaxis. NOTE: Colchicine capsules (i.e., Mitigare) are not FDA-approved for use in pediatrics younger than 18 years old. Find patient medical information for Simvastatin Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Find patient medical information for Colchicine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.